This section presents diagrams for pathways present in exocrine pancreatic cells. Although components known to be present in cells in general may be included to make a complete pathway, the emphasis is on components that have been studied in pancreatic acinar, ductal and stellate cells as well as the pathway initiators and effectors. Each pathway may have associated short Reviews, Molecules and Methods. One aim of this section is to help generate a molecular parts list and interaction diagram that describe pancreatic cells. Community members who establish the presence of specific molecules or isoforms are encouraged to contribute to the Pancreapedia.
Signaling Pathways
- Calcium mobilization by IP3, cADPR, NAADP
- DAG - PKC
- Calcium - Calcineurin - NFAT
- Calcium - calmodulin - CaM kinases
- cAMP - PKA, Epac - Rap1
- PI3K - Akt - mTOR - S6K
- ERK Signaling
- SEK - JNK
- p38MAPK - MAPKAPK2
- Galpha12/13 - RhoA
- TGFbeta - SMAD
- EGFR and other TyrK Mediated Growth Factor Receptors
- Insulin and IGF signaling
- Src - FAK
- NF-κB Signaling
- Notch signaling
- HEDGEHOG SIGNALING
- Hippo Signaling
Functional Pathways
- Neural control of pancreatic function
- Hormonal Control of Pancreatic Function
- Acinar cell digestive enzyme secretion
- Duct cell electrolyte secretion
- Differentiation of pancreatic cell types
- Adaptive pancreatic growth
- Regulation of digestive enzyme (protein) translation
Pathophysiological Pathways
- Cell death pathways
- ER Stress
- Induction of autophagy
- Premature activation of trypsin and pancreatitis
- Acinar-ductal metaplasia and the origin of panins
- Effects of CFTR mutation on the pancreas
- Activation of stellate cells and the induction of fibrosis
- Pancreatic Pain
Newest Pathways
Title | Post date | Pathway Type | Author |
---|---|---|---|
ER Stress | January 28, 2016 | Pathophysiological | John A. Williams |
EGFR and other TyrK Mediated Growth Factor Receptors | April 18, 2013 | Signaling | John A. Williams |
Diacylglycerol-PKC | March 21, 2013 | Signaling | John A. Williams |
Calcium mobilization by IP3, cADPR, NAADP | March 15, 2013 | Signaling | David Yule |
Hippo Signaling | February 18, 2013 | Signaling | John A. Williams |
Pathophysiological Pathways | June 20, 2012 | Signaling | John A. Williams |
Hormonal Control of Pancreatic Function | June 19, 2012 | Functional | John A. Williams |
Pancreatic Pain | June 19, 2012 | Pathophysiological | John A. Williams |
Regulation of NF-kappaB Activation | April 9, 2012 | Signaling | John A. Williams |
Activation of stellate cells and the induction of fibrosis | March 14, 2012 | Pathophysiological | John A. Williams |