Ed: Jami L. Saloman. University of Pittsburgh.
email: jls354@pitt.edu

The Pancreas Animal Models Cnsortium is a group of junior and senior scientist focused on fostering multidisciplinary collaboration as well as sharing knowledge and core resources. There is a large (and growing number of animal models of pancreas disease based on specific signaling pathways, genetic mutations, physical abnormalities, and environmental risk factors. The use of animal models can expand our understanding of the pathophysiology of multi-factorial pancreas diseases and aid in the development and validation of novel therapeutics. This collection of chapters on animal models of pancreas diseases has been developed for the purpose of providing up-to-date detailed information about the available models and how best to utilize them. Our broader objective is to develop consensus guidelines for required and optional endpoints in the analysis of pancreas animal models including pancreatitis and pancreatic cancer.

1. Mouse Models of Trypsin-Dependent Pancreatitis. Miklós Sahin-Tóth. University of California Los Angeles
2. Models of Pancreatitis Caused by Genetic Blockage of Autophagy/Lysosomal Pathway. Anna S. Gukovskaya,^1,2 Olga A. Mareninova,^1,2 Wen-Xing Ding,³ Aida Habtezion,⁴ and Ilya Gukovsky ^1,2. (1) David Geffen School of Medicine, University of California at Los Angeles; (2) VA Greater Los Angeles Healthcare System, Los Angeles, CA; (3) Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas; (4) Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA.
3. Chemically Induced Models of Pancreatitis. Ke-You Zhang,¹ Laura Rosenkrantz,² Zachary M. Sellers¹. (1) Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University, Palo Alto, CA, USA; (2) Division of Gastroenterology, University of Texas Health Center, San Antonio, TX, USA.
4. Chemical Induced Pre-Clinical Models of Pancreatic Cancer. Ranjeet S. Kalsi, Kartikeya Sharma, Mohamed Saleh, Shiho Yoshida, and Farzad Esni. University of Pittsburgh Medical Center Children’s Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224.