This monograph is a summary of the life’s work of the author along with other investigators to study chemical carcinogenesis in the hamster pancreas. It covers the anatomy, physiology, microscopic and fine structure of the hamsters’ pancreas, its diseases, morphologic, biologic and clinical aspects of the induced pancreatic cancer and includes detailed comparison of human and hamster pancreatic cancer in biological, morphological and clinical aspects. The book contains a wealth of histological and ultrastructural illustrations.