I am a pediatric gastroenterologist and basic scientist. I have a clinical interest in pancreatic disorders of childhood, particularly acute and chronic pancreatitis. My research has long centered on the biochemistry and phsyiology of pancreatic lipases and colipase. I use structure-function studies to define the molecular details of lipolysis. I have developed mouse models to study the physiology and developmental changes of pancreatic lipases and colipase.